High-dose vitamin C and cancer

High-dose vitamin C and cancer

Vitamin C (ascorbic acid, ascorbate) is a basic compound that is of great importance with its role in various enzymatic reactions including the synthesis of collagen, as well as with its redox functions. Vitamin C has become the center of interest in cancer studies, in consequence of the facts that connective tissue changes and vitamin C deficiency were first alleged to be associated with cance...

High-Dose Vitamin C A New Therapeutic Approach

Dr. Linus Pauling noted that vitamin C is a critically important water-soluble antioxidant, as it protects proteins and lipids from free radical damage associated with infection, intensive exercise, and other stres-sors that can injure cells.1-3 These very properties make vitamin C a valuable agent for improving immune function. By suppressing oxidative stress, vitamin C increases the life span...

Impact of high dose vitamin C on platelet function

AIM To examine the effect of high doses of vitamin C (VitC) on ex vivo human platelets (PLTs). METHODS Platelet concentrates collected for therapeutic or prophylactic transfusions were exposed to: (1) normal saline (control); (2) 0.3 mmol/L VitC (Lo VitC); or (3) 3 mmol/L VitC (Hi VitC, final concentrations) and stored appropriately. The VitC additive was preservative-free buffered ascorbic a...

High-dose vitamin C therapy: renewed hope or false promise?

Changes of Terminal Cancer Patients' Health-related Quality of Life after High Dose Vitamin C Administration

Over the years there has been a great deal of controversy on the effect of vitamin C on cancer. To investigate the effects of vitamin C on cancer patients' health-related quality of life, we prospectively studied 39 terminal cancer patients. All patients were given an intravenous administration of 10 g vitamin C twice with a 3-day interval and an oral intake of 4 g vitamin C daily for a week. A...